Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study

Using concentration-time data from the NEAT001/ARNS143 study (single sample at week 4 and 24), we determined raltegravir pharmacokinetic parameters using nonlinear mixed effects modelling (NONMEM v.7.3; 602 samples from 349 patients) and investigated the influence of demographics and SNPs (SLC22A6 a...

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Detalles Bibliográficos
Autores principales: Gurjar, Rohan, Dickinson, Laura, Carr, Daniel, Stöhr, Wolfgang, Bonora, Stefano, Owen, Andrew, D’Avolio, Antonio, Cursley, Adam, De Castro, Nathalie, Fätkenheuer, Gerd, Vandekerckhove, Linos, Di Perri, Giovanni, Pozniak, Anton, Schwimmer, Christine, Raffi, François, Boffito, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584256/
https://www.ncbi.nlm.nih.gov/pubmed/36266537
http://dx.doi.org/10.1038/s41397-022-00293-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584256/
https://www.ncbi.nlm.nih.gov/pubmed/36266537
http://dx.doi.org/10.1038/s41397-022-00293-5

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