Cargando…

Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice

The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread occurrence present a pressing need for vaccines. We previously showed that a P. aeruginosa type III secretion system protein, PopB, elicits a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shaikh, Mohammad Omar Faruk, Schaefers, Matthew M., Merakou, Christina, DiBlasi, Marco, Bonney, Sarah, Liao, Tiffany, Zurakowski, David, Kehl, Margaret, Tabor, David E., DiGiandomenico, Antonio, Priebe, Gregory P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Microbial Immunity and Vaccines
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584304/ https://www.ncbi.nlm.nih.gov/pubmed/36069593 http://dx.doi.org/10.1128/iai.00203-22

Ejemplares similares

Controlled Infection Immunization Using Delayed Death Drug Treatment Elicits Protective Immune Responses to Blood-Stage Malaria Parasites
por: Low, Leanne M., et al.
Publicado: (2018)

Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines
por: Lavender, Hayley, et al.
Publicado: (2017)

Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia
por: Sen-Kilic, Emel, et al.
Publicado: (2021)

Characterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization
por: Acquaye-Seedah, Edith, et al.
Publicado: (2018)

Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization
por: Velayutham, Thangam Sudha, et al.
Publicado: (2019)

Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits
por: Dulal, Hari P., et al.
Publicado: (2022)

Development of Subunit Vaccines That Provide High-Level Protection and Sterilizing Immunity against Acute Inhalational Melioidosis
por: Burtnick, Mary N., et al.
Publicado: (2017)

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine
por: Stylianou, Elena, et al.
Publicado: (2018)

Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium
por: Ondari, Edna M., et al.
Publicado: (2017)

Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children
por: Murungi, Linda M., et al.
Publicado: (2016)

A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge
por: Chan, Win-Yan, et al.
Publicado: (2019)

Corrected and Republished from: “A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge”
por: Chan, Win-Yan, et al.
Publicado: (2022)

Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine Model
por: Reeder, Sophia M., et al.
Publicado: (2021)

Antigen Localization Influences the Magnitude and Kinetics of Endogenous Adaptive Immune Response to Recombinant Salmonella Vaccines
por: Sevastsyanovich, Yanina R., et al.
Publicado: (2017)

Efficacy of a Plasmodium vivax Malaria Vaccine Using ChAd63 and Modified Vaccinia Ankara Expressing Thrombospondin-Related Anonymous Protein as Assessed with Transgenic Plasmodium berghei Parasites
por: Bauza, Karolis, et al.
Publicado: (2014)

Vaccination of Cattle with the N Terminus of LppQ of Mycoplasma mycoides subsp. mycoides Results in Type III Immune Complex Disease upon Experimental Infection
por: Mulongo, Musa, et al.
Publicado: (2015)

Monoclonal Antibodies of a Diverse Isotype Induced by an O-Antigen Glycoconjugate Vaccine Mediate In Vitro and In Vivo Killing of African Invasive Nontyphoidal Salmonella
por: Goh, Yun Shan, et al.
Publicado: (2015)

Tailoring a Combination Preerythrocytic Malaria Vaccine
por: Bauza, Karolis, et al.
Publicado: (2016)

Genes Required for the Fitness of Salmonella enterica Serovar Typhimurium during Infection of Immunodeficient gp91(−/−) phox Mice
por: Grant, Andrew J., et al.
Publicado: (2016)

Plasmodium falciparum Gametocyte-Specific Antibody Profiling Reveals Boosting through Natural Infection and Identifies Potential Markers of Gametocyte Exposure
por: Skinner, Jeff, et al.
Publicado: (2015)

The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines
por: Espinosa, Diego A., et al.
Publicado: (2017)

A Subset of Protective γ(9)δ(2) T Cells Is Activated by Novel Mycobacterial Glycolipid Components
por: Xia, Mei, et al.
Publicado: (2016)

Phase Variation of PorA, a Major Outer Membrane Protein, Mediates Escape of Bactericidal Antibodies by Neisseria meningitidis
por: Tauseef, Isfahan, et al.
Publicado: (2013)

Gamma Interferon Is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection
por: Naglak, Elizabeth K., et al.
Publicado: (2016)

The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen
por: Lacey, Keenan A., et al.
Publicado: (2017)

Plasmodium falciparum PfEMP1 Modulates Monocyte/Macrophage Transcription Factor Activation and Cytokine and Chemokine Responses
por: Sampaio, Natália Guimarães, et al.
Publicado: (2017)

The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites
por: Behet, Marije C., et al.
Publicado: (2018)

Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection
por: Giuntini, Serena, et al.
Publicado: (2018)

Tailoring a Plasmodium vivax Vaccine To Enhance Efficacy through a Combination of a CSP Virus-Like Particle and TRAP Viral Vectors
por: Atcheson, Erwan, et al.
Publicado: (2018)

Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host
por: Alhassan, Andy, et al.
Publicado: (2019)

Vaccination against Clostridium difficile by Use of an Attenuated Salmonella enterica Serovar Typhimurium Vector (YS1646) Protects Mice from Lethal Challenge
por: Winter, Kaitlin, et al.
Publicado: (2019)

A Potent and Effective Suicidal Listeria Vaccine Platform
por: Hanson, William G., et al.
Publicado: (2019)

A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas
por: Ysebaert, Carine, et al.
Publicado: (2019)

Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable Haemophilus influenzae Vaccine
por: Blais, Normand, et al.
Publicado: (2019)

Development of Opsonic Mouse Monoclonal Antibodies against Multidrug-Resistant Enterococci
por: Kalfopoulou, Ermioni, et al.
Publicado: (2019)

Assessment of the Plasmodium falciparum Preerythrocytic Antigen UIS3 as a Potential Candidate for a Malaria Vaccine
por: Longley, Rhea J., et al.
Publicado: (2017)

Chemically Attenuated Blood-Stage Plasmodium yoelii Parasites Induce Long-Lived and Strain-Transcending Protection
por: Raja, Amber I., et al.
Publicado: (2016)

Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia
por: Naglak, Elizabeth K., et al.
Publicado: (2017)

Prediction and Validation of Immunogenic Domains of Pneumococcal Proteins Recognized by Human CD4(+) T Cells
por: van de Garde, Martijn D. B., et al.
Publicado: (2019)

Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic Escherichia coli
por: Liu, Yang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kt9aof3uhh3mlk66e3v8d7ao9e