Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eEF1A), which escorts aa-tRNA as an eEF1A(GTP)-aa-tR...

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Detalles Bibliográficos
Autores principales: Juette, Manuel F, Carelli, Jordan D, Rundlet, Emily J, Brown, Alan, Shao, Sichen, Ferguson, Angelica, Wasserman, Michael R, Holm, Mikael, Taunton, Jack, Blanchard, Scott C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584604/
https://www.ncbi.nlm.nih.gov/pubmed/36264623
http://dx.doi.org/10.7554/eLife.81608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584604/
https://www.ncbi.nlm.nih.gov/pubmed/36264623
http://dx.doi.org/10.7554/eLife.81608

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