Epoxyeicosatrienoic Acids Inhibit the Activation of Murine Fibroblasts by Blocking the TGF-β1-Smad2/3 Signaling in a PPARγ-Dependent Manner

BACKGROUND: Epoxyeicosatrienoic acids (EETs), the metabolite of arachidonic acid by cytochrome P450 (CYP), reportedly serve as a vital endogenous protective factor in several chronic diseases. EETs are metabolized by soluble epoxide hydrolase (sEH). We have observed that prophylactic blocking sEH al...

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Detalles Bibliográficos
Autores principales: Tao, Jia-Hao, Liu, Tian, Zhang, Chen-Yu, Zu, Cheng, Yang, Hui-Hui, Liu, Yu-Biao, Yang, Jin-Tong, Zhou, Yong, Guan, Cha-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584742/
https://www.ncbi.nlm.nih.gov/pubmed/36275905
http://dx.doi.org/10.1155/2022/7265486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584742/
https://www.ncbi.nlm.nih.gov/pubmed/36275905
http://dx.doi.org/10.1155/2022/7265486

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