HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracell...

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Detalles Bibliográficos
Autores principales: Chen, Qi-tao, Zhang, Zhi-yuan, Huang, Qiao-ling, Chen, Hang-zi, Hong, Wen-bin, Lin, Tianwei, Zhao, Wen-xiu, Wang, Xiao-min, Ju, Cui-yu, Wu, Liu-zheng, Huang, Ya-ying, Hou, Pei-pei, Wang, Wei-jia, Zhou, Dawang, Deng, Xianming, Wu, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584821/
https://www.ncbi.nlm.nih.gov/pubmed/36192599
http://dx.doi.org/10.1038/s42255-022-00642-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584821/
https://www.ncbi.nlm.nih.gov/pubmed/36192599
http://dx.doi.org/10.1038/s42255-022-00642-5

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