Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A

The mycotoxin ochratoxin A (OTA) is a contaminant in food that causes nephrotoxicity and to a minor degree hepatotoxicity. Recently, we observed that OTA induces liver damage preferentially to the cytochrome P450 (CYP)-expressing pericentral lobular zone, similar to hepatotoxic substances known to b...

Descripción completa

Detalles Bibliográficos
Autores principales: Hassan, Reham, González, Daniela, Hobloss, Zaynab, Brackhagen, Lisa, Myllys, Maiju, Friebel, Adrian, Seddek, Abdel-latif, Marchan, Rosemarie, Cramer, Benedikt, Humpf, Hans-Ulrich, Hoehme, Stefan, Degen, Gisela H., Hengstler, Jan G., Ghallab, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584869/
https://www.ncbi.nlm.nih.gov/pubmed/36227364
http://dx.doi.org/10.1007/s00204-022-03395-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584869/
https://www.ncbi.nlm.nih.gov/pubmed/36227364
http://dx.doi.org/10.1007/s00204-022-03395-y

Ejemplares similares