Cargando…

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A

The mycotoxin ochratoxin A (OTA) is a contaminant in food that causes nephrotoxicity and to a minor degree hepatotoxicity. Recently, we observed that OTA induces liver damage preferentially to the cytochrome P450 (CYP)-expressing pericentral lobular zone, similar to hepatotoxic substances known to b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hassan, Reham, González, Daniela, Hobloss, Zaynab, Brackhagen, Lisa, Myllys, Maiju, Friebel, Adrian, Seddek, Abdel-latif, Marchan, Rosemarie, Cramer, Benedikt, Humpf, Hans-Ulrich, Hoehme, Stefan, Degen, Gisela H., Hengstler, Jan G., Ghallab, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584869/ https://www.ncbi.nlm.nih.gov/pubmed/36227364 http://dx.doi.org/10.1007/s00204-022-03395-y

Ejemplares similares

Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
por: Hassan, Reham, et al.
Publicado: (2022)

Subcellular spatio-temporal intravital kinetics of aflatoxin B(1) and ochratoxin A in liver and kidney
por: Ghallab, Ahmed, et al.
Publicado: (2021)

Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity
por: Hassan, Reham, et al.
Publicado: (2022)

Comparative metabolism of aflatoxin B(1) in mouse, rat and human primary hepatocytes using HPLC–MS/MS
por: Gerdemann, Andrea, et al.
Publicado: (2023)

Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
por: Martínez-Sena, Teresa, et al.
Publicado: (2023)

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice
por: Fendt, Rebekka, et al.
Publicado: (2023)

Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet
por: Custodio, Raly James Perez, et al.
Publicado: (2023)

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
por: Ghallab, Ahmed, et al.
Publicado: (2022)

Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study
por: Ebmeyer, Johanna, et al.
Publicado: (2020)

Autophagy alleviates amiodarone-induced hepatotoxicity
por: Wandrer, Franziska, et al.
Publicado: (2020)

Hepatotoxic combination effects of three azole fungicides in a broad dose range
por: Heise, T., et al.
Publicado: (2017)

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer
por: Kyriakides, Michael, et al.
Publicado: (2016)

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
por: Sison-Young, Rowena L., et al.
Publicado: (2016)

In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity
por: Müller, Fabrice A., et al.
Publicado: (2023)

Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells
por: Louisse, Jochem, et al.
Publicado: (2023)

Transcriptomics analysis of hepatotoxicity induced by the pesticides imazalil, thiacloprid and clothianidin alone or in binary mixtures in a 28-day study in female Wistar rats
por: Alarcan, Jimmy, et al.
Publicado: (2021)

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
por: Herpers, Bram, et al.
Publicado: (2015)

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2016)

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression
por: Ghallab, Ahmed, et al.
Publicado: (2021)

Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
por: Buchmueller, Julia, et al.
Publicado: (2021)

Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance
por: Remetic, Jelena, et al.
Publicado: (2022)

Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
por: Holland, Christian H., et al.
Publicado: (2021)

Acute airway irritation of methyl formate in mice
por: Larsen, Søren T., et al.
Publicado: (2011)

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p′-DDT in U937 macrophages
por: Sciullo, Eric M., et al.
Publicado: (2010)

Lactational coumestrol exposure increases ovarian apoptosis in adult rats
por: Moon, Hyun-Ju, et al.
Publicado: (2009)

Protective effects of curcumin against gamma radiation-induced ileal mucosal damage
por: Akpolat, Meryem, et al.
Publicado: (2008)

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?
por: Joosen, Marloes J. A., et al.
Publicado: (2010)

Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice
por: Kimura, Eiki, et al.
Publicado: (2015)

Optimal experimental designs for dose–response studies with continuous endpoints
por: Holland-Letz, Tim, et al.
Publicado: (2014)

Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA
por: Karlsson, Oskar, et al.
Publicado: (2014)

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis
por: Souza, Terezinha, et al.
Publicado: (2015)

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile
por: Heslop, James A., et al.
Publicado: (2016)

High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
por: Su, Ran, et al.
Publicado: (2015)

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
por: Ramirez, Tzutzuy, et al.
Publicado: (2017)

GABA(A) receptor subtype selectivity of the proconvulsant rodenticide TETS
por: Pressly, Brandon, et al.
Publicado: (2017)

Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation
por: Barosova, Hana, et al.
Publicado: (2018)

Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity
por: Luz, Matthias, et al.
Publicado: (2018)

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
por: Tolosa, Laia, et al.
Publicado: (2017)

Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity
por: Cheng, Lili, et al.
Publicado: (2017)

Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices
por: Berndt, Nikolaus, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_aog4og27cfd70a11flij10v0ts