Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity

BACKGROUND: To verify the validity of the proposed pain treatment approach, which is based on concomitant blocking of the Transient Receptor Potential Ankyrin 1 (TRPA1) channel and phosphodiesterases (PDEs) 4B/7A activity, we continued our pharmacological studies on 8-alkoxypurine-2,6-diones selecte...

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Detalles Bibliográficos
Autores principales: Zygmunt, Małgorzata, Ślusarczyk, Marietta, Jankowska, Agnieszka, Świerczek, Artur, Bryła, Adrian, Mogilski, Szczepan, Kazek, Grzegorz, Sapa, Jacek, Wyska, Elżbieta, Chłoń-Rzepa, Grażyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584878/
https://www.ncbi.nlm.nih.gov/pubmed/35930193
http://dx.doi.org/10.1007/s43440-022-00397-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584878/
https://www.ncbi.nlm.nih.gov/pubmed/35930193
http://dx.doi.org/10.1007/s43440-022-00397-6

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