Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility

Outer hair cell elecromotility, driven by prestin, is essential for mammalian cochlear amplification. Here, we report the cryo-EM structures of thermostabilized prestin (Pres(TS)), complexed with chloride, sulfate, or salicylate at 3.52-3.63 Å resolutions. The central positively-charged cavity allow...

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Detalles Bibliográficos
Autores principales: Futamata, Haon, Fukuda, Masahiro, Umeda, Rie, Yamashita, Keitaro, Tomita, Atsuhiro, Takahashi, Satoe, Shikakura, Takafumi, Hayashi, Shigehiko, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Homma, Kazuaki, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584906/
https://www.ncbi.nlm.nih.gov/pubmed/36266333
http://dx.doi.org/10.1038/s41467-022-34017-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584906/
https://www.ncbi.nlm.nih.gov/pubmed/36266333
http://dx.doi.org/10.1038/s41467-022-34017-x

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