Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3

TET (Ten-Eleven Translocation) dioxygenases effect DNA demethylation through successive oxidation of the methyl group of 5-methylcytosine (5mC) in DNA. In humans and in mouse models, TET loss-of-function has been linked to DNA damage, genome instability and oncogenesis. Here we show that acute delet...

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Detalles Bibliográficos
Autores principales: Georges, Romain O., Sepulveda, Hugo, Angel, J. Carlos, Johnson, Eric, Palomino, Susan, Nowak, Roberta B., Desai, Arshad, López-Moyado, Isaac F., Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584922/
https://www.ncbi.nlm.nih.gov/pubmed/36266342
http://dx.doi.org/10.1038/s41467-022-33742-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584922/
https://www.ncbi.nlm.nih.gov/pubmed/36266342
http://dx.doi.org/10.1038/s41467-022-33742-7

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