The LRP1/CD91 ligands, tissue-type plasminogen activator, α(2)-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling

LDL Receptor-related Protein-1 (LRP1/CD91) binds diverse ligands, many of which activate cell-signaling. Herein, we compared three LRP1 ligands that inhibit inflammatory responses triggered by lipopolysaccharide (LPS), including: enzymatically-inactive tissue-type plasminogen activator (EI-tPA); act...

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Detalles Bibliográficos
Autores principales: Mantuano, Elisabetta, Azmoon, Pardis, Banki, Michael A., Gunner, Cory B., Gonias, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585055/
https://www.ncbi.nlm.nih.gov/pubmed/36266319
http://dx.doi.org/10.1038/s41598-022-22498-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585055/
https://www.ncbi.nlm.nih.gov/pubmed/36266319
http://dx.doi.org/10.1038/s41598-022-22498-1

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