Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT(MyoD)) to injured tissue in vivo. TNT(MyoD) was performed on skin and successfully induced expression of myogenic factors. TNT(MyoD) was then used as a therapy 7 days following volumetric muscle loss (VML) o...

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Autores principales: Clark, Andrew, Ghatak, Subhadip, Guda, Poornachander Reddy, El Masry, Mohamed S., Xuan, Yi, Sato, Amy Y., Bellido, Teresita, Sen, Chandan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585072/
https://www.ncbi.nlm.nih.gov/pubmed/36266362
http://dx.doi.org/10.1038/s41536-022-00259-y
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author Clark, Andrew
Ghatak, Subhadip
Guda, Poornachander Reddy
El Masry, Mohamed S.
Xuan, Yi
Sato, Amy Y.
Bellido, Teresita
Sen, Chandan K.
author_facet Clark, Andrew
Ghatak, Subhadip
Guda, Poornachander Reddy
El Masry, Mohamed S.
Xuan, Yi
Sato, Amy Y.
Bellido, Teresita
Sen, Chandan K.
author_sort Clark, Andrew
collection PubMed
description This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT(MyoD)) to injured tissue in vivo. TNT(MyoD) was performed on skin and successfully induced expression of myogenic factors. TNT(MyoD) was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT(MyoD) is promising as VML intervention.
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spelling pubmed-95850722022-10-22 Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss Clark, Andrew Ghatak, Subhadip Guda, Poornachander Reddy El Masry, Mohamed S. Xuan, Yi Sato, Amy Y. Bellido, Teresita Sen, Chandan K. NPJ Regen Med Brief Communication This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT(MyoD)) to injured tissue in vivo. TNT(MyoD) was performed on skin and successfully induced expression of myogenic factors. TNT(MyoD) was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT(MyoD) is promising as VML intervention. Nature Publishing Group UK 2022-10-20 /pmc/articles/PMC9585072/ /pubmed/36266362 http://dx.doi.org/10.1038/s41536-022-00259-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Clark, Andrew
Ghatak, Subhadip
Guda, Poornachander Reddy
El Masry, Mohamed S.
Xuan, Yi
Sato, Amy Y.
Bellido, Teresita
Sen, Chandan K.
Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
title Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
title_full Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
title_fullStr Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
title_full_unstemmed Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
title_short Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
title_sort myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585072/
https://www.ncbi.nlm.nih.gov/pubmed/36266362
http://dx.doi.org/10.1038/s41536-022-00259-y
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