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Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV

BACKGROUND AND AIMS: Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining characteristics, including liver tropism, chronicity, and pat...

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Detalles Bibliográficos
Autores principales: Wolfisberg, Raphael, Thorselius, Caroline E., Salinas, Eduardo, Elrod, Elizabeth, Trivedi, Sheetal, Nielsen, Louise, Fahnøe, Ulrik, Kapoor, Amit, Grakoui, Arash, Rice, Charles M., Bukh, Jens, Holmbeck, Kenn, Scheel, Troels K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585093/
https://www.ncbi.nlm.nih.gov/pubmed/35445423
http://dx.doi.org/10.1002/hep.32535