A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues

Drug resistance to front-line malarial treatments represents an ongoing threat to control malaria, a vector borne infectious disease. The malarial parasite, Plasmodium falciparum has developed genetic variants, conferring resistance to the current standard therapeutic artemisinin and its derivatives...

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Detalles Bibliográficos
Autores principales: Mrozek, Alexander, Antoshchenko, Tetyana, Chen, Yun, Zepeda-Velázquez, Carlos, Smil, David, Kumar, Nirbhay, Lu, Hua, Park, Hee-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585173/
https://www.ncbi.nlm.nih.gov/pubmed/36275624
http://dx.doi.org/10.3389/fmolb.2022.956095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585173/
https://www.ncbi.nlm.nih.gov/pubmed/36275624
http://dx.doi.org/10.3389/fmolb.2022.956095

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