Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage

Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell susceptibility or resist...

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Detalles Bibliográficos
Autores principales: Chen, Jing, Li, Renhua, Knapp, Sarah, Zhu, Guizhi, Whitener, Robert L., Leiter, Edward H., Mathews, Clayton E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585181/
https://www.ncbi.nlm.nih.gov/pubmed/36276935
http://dx.doi.org/10.3389/fgene.2022.994501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585181/
https://www.ncbi.nlm.nih.gov/pubmed/36276935
http://dx.doi.org/10.3389/fgene.2022.994501

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