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Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage

Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell susceptibility or resist...

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Detalles Bibliográficos
Autores principales:	Chen, Jing, Li, Renhua, Knapp, Sarah, Zhu, Guizhi, Whitener, Robert L., Leiter, Edward H., Mathews, Clayton E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585181/ https://www.ncbi.nlm.nih.gov/pubmed/36276935 http://dx.doi.org/10.3389/fgene.2022.994501

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