SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

The study is based on using SeDeM expert system in developing controlled-release tramadol HCl osmotic tablets and its in-silico physiologically based pharmacokinetic (PBPK) modeling for in-vivo pharmacokinetic evaluation. A Quality by Design (QbD) based approach in developing SeDEM-driven full facto...

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Detalles Bibliográficos
Autores principales: Saleem, Muhammad Talha, Shoaib, Muhammad Harris, Yousuf, Rabia Ismail, Ahmed, Farrukh Rafiq, Ahmed, Kamran, Siddiqui, Fahad, Mahmood, Zafar Alam, Sikandar, Muhammad, Imtiaz, Muhammad Suleman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585207/
https://www.ncbi.nlm.nih.gov/pubmed/36278217
http://dx.doi.org/10.3389/fphar.2022.974715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585207/
https://www.ncbi.nlm.nih.gov/pubmed/36278217
http://dx.doi.org/10.3389/fphar.2022.974715

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