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Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region

The Mycobacterium tuberculosis genome harbours nine toxin-antitoxin (TA) systems of the mazEF family. These consist of two proteins, a toxin and an antitoxin, encoded in an operon. While the toxin has a conserved fold, the antitoxins are structurally diverse and the toxin binding region is typically...

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Detalles Bibliográficos
Autores principales: Ahmed, Shahbaz, Chattopadhyay, Gopinath, Manjunath, Kavyashree, Bhasin, Munmun, Singh, Neelam, Rasool, Mubashir, Das, Sayan, Rana, Varsha, Khan, Neha, Mitra, Debarghya, Asok, Aparna, Singh, Ramandeep, Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585320/
https://www.ncbi.nlm.nih.gov/pubmed/36275627
http://dx.doi.org/10.3389/fmolb.2022.997653