High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) represent an excellent in vitro model in cardiovascular research. Changes in their action potential (AP) dynamics convey information that is essential for disease modeling, drug screening and toxicity evaluation. High-th...

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Detalles Bibliográficos
Autores principales: Zhang, Fangfang, Meier, Anna B., Poch, Christine M., Tian, Qinghai, Engelhardt, Stefan, Sinnecker, Daniel, Lipp, Peter, Laugwitz, Karl-Ludwig, Moretti, Alessandra, Dorn, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585323/
https://www.ncbi.nlm.nih.gov/pubmed/36274846
http://dx.doi.org/10.3389/fcell.2022.1038867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585323/
https://www.ncbi.nlm.nih.gov/pubmed/36274846
http://dx.doi.org/10.3389/fcell.2022.1038867

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