Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues

[Image: see text] Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. S1P has been implicated in a variety of pathologies including cancer, kidney fibrosis, and mu...

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Detalles Bibliográficos
Autores principales: Pashikanti, Srinath, Foster, Daniel J., Kharel, Yugesh, Brown, Anne M., Bevan, David R., Lynch, Kevin R., Santos, Webster L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585524/
https://www.ncbi.nlm.nih.gov/pubmed/36281302
http://dx.doi.org/10.1021/acsbiomedchemau.2c00017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585524/
https://www.ncbi.nlm.nih.gov/pubmed/36281302
http://dx.doi.org/10.1021/acsbiomedchemau.2c00017

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