CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 nuclease system has allowed the generation of disease models and the development of therapeutic approaches for many genetic and non-genetic disorders. However, the generation of large genomic rearrangements has raised safety...

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Detalles Bibliográficos
Autores principales: Amendola, Mario, Brusson, Mégane, Miccio, Annarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585945/
https://www.ncbi.nlm.nih.gov/pubmed/36048170
http://dx.doi.org/10.1093/stcltm/szac064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585945/
https://www.ncbi.nlm.nih.gov/pubmed/36048170
http://dx.doi.org/10.1093/stcltm/szac064

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