Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells

Metabolic reprogramming is now considered a hallmark of cancer cells. KRas-driven cancer cells use glutaminolysis to generate the tricarboxylic acid cycle intermediate α-ketoglutarate via a transamination reaction between glutamate and oxaloacetate. We reported previously that exogenously supplied u...

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Detalles Bibliográficos
Autores principales: Hatipoglu, Ahmet, Menon, Deepak, Levy, Talia, Frias, Maria A., Foster, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586366/
https://www.ncbi.nlm.nih.gov/pubmed/36269753
http://dx.doi.org/10.1371/journal.pone.0276579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586366/
https://www.ncbi.nlm.nih.gov/pubmed/36269753
http://dx.doi.org/10.1371/journal.pone.0276579

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