Decoupling the role of RORγt in the differentiation and effector function of T(H)17 cells

RORγt is known to instruct the differentiation of T helper 17 (T(H)17) cells that mediate the pathogenesis of autoimmune diseases. However, it remains unknown whether RORγt plays a distinct role in the differentiation and effector function of T(H)17 cells. Here, we show that mutation of RORγt lysine...

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Detalles Bibliográficos
Autores principales: Zhong, Xiancai, Wu, Hongmin, Zhang, Wencan, Gwack, Yousang, Shang, Weirong, Lee, Kyle O., Isakov, Noah, He, Zhiheng, Sun, Zuoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586477/
https://www.ncbi.nlm.nih.gov/pubmed/36269826
http://dx.doi.org/10.1126/sciadv.adc9221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586477/
https://www.ncbi.nlm.nih.gov/pubmed/36269826
http://dx.doi.org/10.1126/sciadv.adc9221

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