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Decoupling the role of RORγt in the differentiation and effector function of T(H)17 cells

RORγt is known to instruct the differentiation of T helper 17 (T(H)17) cells that mediate the pathogenesis of autoimmune diseases. However, it remains unknown whether RORγt plays a distinct role in the differentiation and effector function of T(H)17 cells. Here, we show that mutation of RORγt lysine...

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Detalles Bibliográficos
Autores principales:	Zhong, Xiancai, Wu, Hongmin, Zhang, Wencan, Gwack, Yousang, Shang, Weirong, Lee, Kyle O., Isakov, Noah, He, Zhiheng, Sun, Zuoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586477/ https://www.ncbi.nlm.nih.gov/pubmed/36269826 http://dx.doi.org/10.1126/sciadv.adc9221

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