The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining

The RING-type E3 ubiquitin ligases RNF8 and RNF168 recruit DNA damage response (DDR) factors to chromatin flanking DNA double strand breaks (DSBs) including 53BP1, which protects DNA ends from resection during DNA DSB repair by non-homologous end joining (NHEJ). Deficiency of RNF8 or RNF168 does not...

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Detalles Bibliográficos
Autores principales: Chen, Bo-Ruei, Wang, Yinan, Shen, Zih-Jie, Bennett, Amelia, Hindi, Issa, Tyler, Jessica K., Sleckman, Barry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586520/
https://www.ncbi.nlm.nih.gov/pubmed/34481157
http://dx.doi.org/10.1016/j.dnarep.2021.103217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586520/
https://www.ncbi.nlm.nih.gov/pubmed/34481157
http://dx.doi.org/10.1016/j.dnarep.2021.103217

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