Na(v)1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Na(v)1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP participants and n = 86 healthy controls) and facial electr...

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Detalles Bibliográficos
Autores principales: Middleton, Steven J, Perini, Irene, Themistocleous, Andreas C, Weir, Greg A, McCann, Kirsty, Barry, Allison M, Marshall, Andrew, Lee, Michael, Mayo, Leah M, Bohic, Manon, Baskozos, Georgios, Morrison, India, Löken, Line S, McIntyre, Sarah, Nagi, Saad S, Staud, Roland, Sehlstedt, Isac, Johnson, Richard D, Wessberg, Johan, Wood, John N, Woods, Christopher G, Moqrich, Aziz, Olausson, Håkan, Bennett, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586547/
https://www.ncbi.nlm.nih.gov/pubmed/34957475
http://dx.doi.org/10.1093/brain/awab482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586547/
https://www.ncbi.nlm.nih.gov/pubmed/34957475
http://dx.doi.org/10.1093/brain/awab482

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