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Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner
At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1(SS4+)) and neurexin-3 (Nrxn3(SS4+)) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1(SS4+) and Nrxn3(SS4+) act by binding to secreted cerebellin-2 (Cbln2) that in turn activ...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586558/ https://www.ncbi.nlm.nih.gov/pubmed/36205393 http://dx.doi.org/10.7554/eLife.78649 |