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Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1(SS4+)) and neurexin-3 (Nrxn3(SS4+)) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1(SS4+) and Nrxn3(SS4+) act by binding to secreted cerebellin-2 (Cbln2) that in turn activ...

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Detalles Bibliográficos
Autores principales:	Dai, Jinye, Liakath-Ali, Kif, Golf, Samantha Rose, Südhof, Thomas C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586558/ https://www.ncbi.nlm.nih.gov/pubmed/36205393 http://dx.doi.org/10.7554/eLife.78649

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