Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting CD105 (endoglin), a component of the TGFβ rec...

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Detalles Bibliográficos
Autores principales: Lontos, Konstantinos, Wang, Yiyang, Colbert, Mason, Kumar, Alok, Joshi, Supriya, Philbin, Mary, Wang, Yupeng, Frisch, Andrew, Lohmueller, Jason, Rivadeneira, Dayana B., Delgoffe, Greg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586682/
https://www.ncbi.nlm.nih.gov/pubmed/36275862
http://dx.doi.org/10.1080/2162402X.2022.2131229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586682/
https://www.ncbi.nlm.nih.gov/pubmed/36275862
http://dx.doi.org/10.1080/2162402X.2022.2131229

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