PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination

The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an intrinsic driver for oligodendroglial development and myelination. Genetic PARP1 depletion impairs the differentiation of ol...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Zhang, Yanhong, Zhang, Sheng, Kim, Bokyung, Hull, Vanessa L., Xu, Jie, Prabhu, Preeti, Gregory, Maria, Martinez-Cerdeno, Veronica, Zhan, Xinhua, Deng, Wenbin, Guo, Fuzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586836/
https://www.ncbi.nlm.nih.gov/pubmed/34610310
http://dx.doi.org/10.1016/j.celrep.2021.109695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586836/
https://www.ncbi.nlm.nih.gov/pubmed/34610310
http://dx.doi.org/10.1016/j.celrep.2021.109695

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