Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits

Functional genomic methods are needed that consider multiple genetically correlated traits. Here we develop and validate Transcriptome-wide Structural Equation Modeling (T-SEM), a multivariate method for studying the effects of tissue-specific gene expression across genetically overlapping traits. T...

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Detalles Bibliográficos
Autores principales: Grotzinger, Andrew D., de la Fuente, Javier, Davies, Gail, Nivard, Michel G., Tucker-Drob, Elliot M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586980/
https://www.ncbi.nlm.nih.gov/pubmed/36271044
http://dx.doi.org/10.1038/s41467-022-33724-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586980/
https://www.ncbi.nlm.nih.gov/pubmed/36271044
http://dx.doi.org/10.1038/s41467-022-33724-9

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