Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life

The cytosolic molecular chaperone Hsp90 is essential for eukaryotic life. Although reduced Hsp90 levels correlate with aging, it was unknown whether eukaryotic cells and organisms can tune the basal Hsp90 levels to alleviate physiologically accumulated stress. We have investigated whether and how mi...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Kaushik, Maiti, Samarpan, Zahoran, Szabolcs, Weidenauer, Lorenz, Hany, Dina, Wider, Diana, Bernasconi, Lilia, Quadroni, Manfredo, Collart, Martine, Picard, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587034/
https://www.ncbi.nlm.nih.gov/pubmed/36270993
http://dx.doi.org/10.1038/s41467-022-33916-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587034/
https://www.ncbi.nlm.nih.gov/pubmed/36270993
http://dx.doi.org/10.1038/s41467-022-33916-3

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