Blocking autophagy with chloroquine aggravates lipid accumulation and reduces intracellular energy synthesis in hepatocellular carcinoma cells, both contributing to its anti-proliferative effect

PURPOSE: The autophagy inhibitor chloroquine enhances the effect of targeted therapy using tyrosine kinase inhibitor in liver cancer. We would like to further understand the specific mechanism by which chloroquine inhibits the proliferation of tumor cells. METHODS: We used a human hepatocarcinoma ce...

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Detalles Bibliográficos
Autores principales: Xu, Fengming, Tautenhahn, Hans-Michael, Dirsch, Olaf, Dahmen, Uta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article – Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587105/
https://www.ncbi.nlm.nih.gov/pubmed/35695930
http://dx.doi.org/10.1007/s00432-022-04074-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587105/
https://www.ncbi.nlm.nih.gov/pubmed/35695930
http://dx.doi.org/10.1007/s00432-022-04074-2

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