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Interactions in the 2×2×2 factorial randomised clinical STEPCARE trial and the potential effects on conclusions: a protocol for a simulation study

BACKGROUND: Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions have no interactions on outcomes. Here, we present a protocol for a simulation st...

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Detalles Bibliográficos
Autores principales: Olsen, Markus Harboe, Jensen, Aksel Karl Georg, Dankiewicz, Josef, Skrifvars, Markus B., Reinikainen, Matti, Tiainen, Marjaana, Saxena, Manoj, Aneman, Anders, Gluud, Christian, Ullén, Susann, Nielsen, Niklas, Jakobsen, Janus Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587583/
https://www.ncbi.nlm.nih.gov/pubmed/36273179
http://dx.doi.org/10.1186/s13063-022-06796-7