Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

BACKGROUND: Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis. Super enhancers (SEs) are large clusters of enhancers that play important roles in cancer through transcriptional control of cell identity genes, o...

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Detalles Bibliográficos
Autores principales: Li, Meng, Han, Yujie, Wang, Chaochen, Kang, Wenfeng, Jiang, Wenyan, Zhang, Lei, Tang, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587669/
https://www.ncbi.nlm.nih.gov/pubmed/36273157
http://dx.doi.org/10.1186/s13046-022-02506-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587669/
https://www.ncbi.nlm.nih.gov/pubmed/36273157
http://dx.doi.org/10.1186/s13046-022-02506-y

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