Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560

Inhibition of γ-secretase activity represents a potential therapeutic strategy for Alzheimer’s disease (AD). MRK-560 is a selective inhibitor with higher potency for Presenilin 1 (PS1) than for PS2, the two isoforms of the catalytic subunit of γ-secretase, although the underlying mechanism remains e...

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Detalles Bibliográficos
Autores principales: Guo, Xuefei, Wang, Yumeng, Zhou, Jiayao, Jin, Chen, Wang, Jiaoni, Jia, Bojun, Jing, Dan, Yan, Chuangye, Lei, Jianlin, Zhou, Rui, Shi, Yigong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587990/
https://www.ncbi.nlm.nih.gov/pubmed/36272978
http://dx.doi.org/10.1038/s41467-022-33817-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587990/
https://www.ncbi.nlm.nih.gov/pubmed/36272978
http://dx.doi.org/10.1038/s41467-022-33817-5

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