Noxa and Mcl-1 expression influence the sensitivity to BH3-mimetics that target Bcl-xL in patient-derived glioma stem cells

The recurrence of Glioblastoma is partly attributed to the highly resistant subpopulation of glioma stem cells. A novel therapeutic approach focuses on restoring apoptotic programs in these cancer stem cells, as they are often deregulated. BH3-mimetics, targeting anti-apoptotic Bcl-2 family members,...

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Detalles Bibliográficos
Autores principales: Vera, Mariana Belén, Morris-Hanon, Olivia, Nogueiras, Germán Ignacio, Ripari, Luisina Belén, Esquivel, Myrian Inés, Perez-Castro, Carolina, Romorini, Leonardo, Sevlever, Gustavo Emilio, Scassa, María Elida, Videla-Richardson, Guillermo Agustín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587994/
https://www.ncbi.nlm.nih.gov/pubmed/36273072
http://dx.doi.org/10.1038/s41598-022-20910-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587994/
https://www.ncbi.nlm.nih.gov/pubmed/36273072
http://dx.doi.org/10.1038/s41598-022-20910-4

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