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Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability

ASARs are long noncoding RNA genes that control replication timing of entire human chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 and 15, and are essential for chromosome integrity. To identify ASARs on all human chromosomes we utilize a set of distinctive ASAR cha...

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Autores principales: Heskett, Michael B., Vouzas, Athanasios E., Smith, Leslie G., Yates, Phillip A., Boniface, Christopher, Bouhassira, Eric E., Spellman, Paul T., Gilbert, David M., Thayer, Mathew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588035/
https://www.ncbi.nlm.nih.gov/pubmed/36273230
http://dx.doi.org/10.1038/s41467-022-34099-7
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author Heskett, Michael B.
Vouzas, Athanasios E.
Smith, Leslie G.
Yates, Phillip A.
Boniface, Christopher
Bouhassira, Eric E.
Spellman, Paul T.
Gilbert, David M.
Thayer, Mathew J.
author_facet Heskett, Michael B.
Vouzas, Athanasios E.
Smith, Leslie G.
Yates, Phillip A.
Boniface, Christopher
Bouhassira, Eric E.
Spellman, Paul T.
Gilbert, David M.
Thayer, Mathew J.
author_sort Heskett, Michael B.
collection PubMed
description ASARs are long noncoding RNA genes that control replication timing of entire human chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 and 15, and are essential for chromosome integrity. To identify ASARs on all human chromosomes we utilize a set of distinctive ASAR characteristics that allow for the identification of hundreds of autosomal loci with epigenetically controlled, allele-restricted behavior in expression and replication timing of coding and noncoding genes, and is distinct from genomic imprinting. Disruption of noncoding RNA genes at five of five tested loci result in chromosome-wide delayed replication and chromosomal instability, validating their ASAR activity. In addition to the three known essential cis-acting chromosomal loci, origins, centromeres, and telomeres, we propose that all mammalian chromosomes also contain “Inactivation/Stability Centers” that display allele-restricted epigenetic regulation of protein coding and noncoding ASAR genes that are essential for replication and stability of each chromosome.
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spelling pubmed-95880352022-10-24 Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability Heskett, Michael B. Vouzas, Athanasios E. Smith, Leslie G. Yates, Phillip A. Boniface, Christopher Bouhassira, Eric E. Spellman, Paul T. Gilbert, David M. Thayer, Mathew J. Nat Commun Article ASARs are long noncoding RNA genes that control replication timing of entire human chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 and 15, and are essential for chromosome integrity. To identify ASARs on all human chromosomes we utilize a set of distinctive ASAR characteristics that allow for the identification of hundreds of autosomal loci with epigenetically controlled, allele-restricted behavior in expression and replication timing of coding and noncoding genes, and is distinct from genomic imprinting. Disruption of noncoding RNA genes at five of five tested loci result in chromosome-wide delayed replication and chromosomal instability, validating their ASAR activity. In addition to the three known essential cis-acting chromosomal loci, origins, centromeres, and telomeres, we propose that all mammalian chromosomes also contain “Inactivation/Stability Centers” that display allele-restricted epigenetic regulation of protein coding and noncoding ASAR genes that are essential for replication and stability of each chromosome. Nature Publishing Group UK 2022-10-22 /pmc/articles/PMC9588035/ /pubmed/36273230 http://dx.doi.org/10.1038/s41467-022-34099-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Heskett, Michael B.
Vouzas, Athanasios E.
Smith, Leslie G.
Yates, Phillip A.
Boniface, Christopher
Bouhassira, Eric E.
Spellman, Paul T.
Gilbert, David M.
Thayer, Mathew J.
Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
title Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
title_full Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
title_fullStr Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
title_full_unstemmed Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
title_short Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
title_sort epigenetic control of chromosome-associated lncrna genes essential for replication and stability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588035/
https://www.ncbi.nlm.nih.gov/pubmed/36273230
http://dx.doi.org/10.1038/s41467-022-34099-7
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