PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141(+) cancer-associated fibroblasts in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients with PDAC display limited benefits after undergoing chemotherapy or immunotherapy modalities. Herein, we reveal that chemotherapy upregulates placental growth factor (PlGF), which directly activates cancer-asso...

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Detalles Bibliográficos
Autores principales: Kim, Duk Ki, Jeong, Juhee, Lee, Dong Sun, Hyeon, Do Young, Park, Geon Woo, Jeon, Suwan, Lee, Kyung Bun, Jang, Jin-Young, Hwang, Daehee, Kim, Ho Min, Jung, Keehoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588060/
https://www.ncbi.nlm.nih.gov/pubmed/36272973
http://dx.doi.org/10.1038/s41467-022-33991-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588060/
https://www.ncbi.nlm.nih.gov/pubmed/36272973
http://dx.doi.org/10.1038/s41467-022-33991-6

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