Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction

BACKGROUND: T-cell longevity is undermined by antigen-driven differentiation programs that render cells prone to attrition through several mechanisms. CD8 (+ )T cells that express the Tcf-1 transcription factor have undergone limited differentiation and exhibit stem-cell-like replenishment functions...

Descripción completa

Detalles Bibliográficos
Autores principales: Zangari, Brendan, Tsuji, Takemasa, Matsuzaki, Junko, Mohammadpour, Hemn, Eppolito, Cheryl, Battaglia, Sebastiano, Ito, Fumito, Chodon, Thinle, Koya, Richard, Robert McGray, A. J., Odunsi, Kunle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588092/
https://www.ncbi.nlm.nih.gov/pubmed/35460379
http://dx.doi.org/10.1007/s00262-022-03197-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588092/
https://www.ncbi.nlm.nih.gov/pubmed/35460379
http://dx.doi.org/10.1007/s00262-022-03197-2

Ejemplares similares