Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm

Vascular smooth muscle cell (VSMC) phenotypic modulation regulates the initiation and progression of intracranial aneurysm (IA). Dexmedetomidine (DEX) is suggested to play neuroprotective roles in patients with craniocerebral injury. Therefore, we investigated the biological functions of DEX and its...

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Detalles Bibliográficos
Autores principales: Zhang, Ze, Mu, Xiue, Zhou, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588221/
https://www.ncbi.nlm.nih.gov/pubmed/36273189
http://dx.doi.org/10.1186/s40360-022-00607-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588221/
https://www.ncbi.nlm.nih.gov/pubmed/36273189
http://dx.doi.org/10.1186/s40360-022-00607-0

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