Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin

BACKGROUND: DNA ligases are crucial for DNA repair and cell replication since they catalyze the final steps in which DNA breaks are joined. DNA Ligase III (LIG3) exerts a pivotal role in Alternative-Non-Homologous End Joining Repair (Alt-NHEJ), an error-prone DNA repair pathway often up-regulated in...

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Detalles Bibliográficos
Autores principales: Caracciolo, Daniele, Juli, Giada, Riillo, Caterina, Coricello, Adriana, Vasile, Francesca, Pollastri, Sara, Rocca, Roberta, Scionti, Francesca, Polerà, Nicoletta, Grillone, Katia, Arbitrio, Mariamena, Staropoli, Nicoletta, Caparello, Basilio, Britti, Domenico, Loprete, Giovanni, Costa, Giosuè, Di Martino, Maria Teresa, Alcaro, Stefano, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588242/
https://www.ncbi.nlm.nih.gov/pubmed/36273153
http://dx.doi.org/10.1186/s12967-022-03705-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588242/
https://www.ncbi.nlm.nih.gov/pubmed/36273153
http://dx.doi.org/10.1186/s12967-022-03705-z

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