SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca(2+)

Post‐translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin I can also be modified by SUMOylation at lysine 177. Functio...

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Detalles Bibliográficos
Autores principales: Fertig, Bracy, Ling, Jiayue, Nollet, Edgar E., Dobi, Sara, Busiau, Tara, Ishikawa, Kiyotake, Yamada, Kelly, Lee, Ahyoung, Kho, Changwon, Wills, Lauren, Tibbo, Amy J., Scott, Mark, Grant, Kirsten, Campbell, Kenneth S., Birks, Emma J., MacQuaide, Niall, Hajjar, Roger, Smith, Godfrey L., van der Velden, Jolanda, Baillie, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588612/
https://www.ncbi.nlm.nih.gov/pubmed/35633070
http://dx.doi.org/10.1111/febs.16537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588612/
https://www.ncbi.nlm.nih.gov/pubmed/35633070
http://dx.doi.org/10.1111/febs.16537

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