Regio‐ and Stereoselective 1,2‐Oxyhalogenation of Non‐Conjugated Alkynes via Directed Nucleopalladation: Catalytic Access to Tetrasubstituted Alkenes

A catalytic 1,2‐oxyhalogenation method that converts non‐conjugated internal alkynes into tetrasubstituted alkenes with high regio‐ and stereoselectivity is described. Mechanistically, the reaction involves a Pd(II)/Pd(IV) catalytic cycle that begins with a directed oxypalladation step. The origin o...

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Detalles Bibliográficos
Autores principales: Liu, Mingyu, Sun, Juntao, Zhang, Tao, Ding, Yi, Han, Ye‐Qiang, Martín‐Montero, Raúl, Lan, Yu, Shi, Bing‐Feng, Engle, Keary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588632/
https://www.ncbi.nlm.nih.gov/pubmed/36082442
http://dx.doi.org/10.1002/anie.202209099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588632/
https://www.ncbi.nlm.nih.gov/pubmed/36082442
http://dx.doi.org/10.1002/anie.202209099

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