Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progresses and spreads by metastasis to the liver(1). Cancer-associated fibroblasts, the extracellular matrix and type I collagen (Col I) support(2,3) or restrain the progression of PDAC and may imped...

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Detalles Bibliográficos
Autores principales: Su, Hua, Yang, Fei, Fu, Rao, Trinh, Brittney, Sun, Nina, Liu, Junlai, Kumar, Avi, Baglieri, Jacopo, Siruno, Jeremy, Le, Michelle, Li, Yuhan, Dozier, Stephen, Nair, Ajay, Filliol, Aveline, Sinchai, Nachanok, Rosenthal, Sara Brin, Santini, Jennifer, Metallo, Christian M., Molina, Anthony, Schwabe, Robert F., Lowy, Andrew M., Brenner, David, Sun, Beicheng, Karin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588640/
https://www.ncbi.nlm.nih.gov/pubmed/36198801
http://dx.doi.org/10.1038/s41586-022-05169-z

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