Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis

Whereas it is appreciated that cancer cells rewire lipid metabolism to survive and propagate, the roles of lipid metabolism in metastasis remain largely unknown. In this study, using esophageal squamous cell carcinoma (ESCC) as a pulmonary metastasis model, we find that the enzyme fatty acid 2-hydro...

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Detalles Bibliográficos
Autores principales: Zhou, Xuantong, Huang, Furong, Ma, Gang, Wei, Wenqing, Wu, Nan, Liu, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588768/
https://www.ncbi.nlm.nih.gov/pubmed/36274060
http://dx.doi.org/10.1038/s41392-022-01199-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588768/
https://www.ncbi.nlm.nih.gov/pubmed/36274060
http://dx.doi.org/10.1038/s41392-022-01199-1

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