Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer

Bromodomain and extraterminal (BET) proteins including BRD4 play important roles in oncogenesis and immune inflammation. Here we demonstrate that cancer cells with loss of the retinoblastoma (RB) tumor suppressor became resistant to small molecule bromodomain inhibitors of BET proteins. We find that...

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Detalles Bibliográficos
Autores principales: Ding, Donglin, Zheng, Rongbin, Tian, Ye, Jimenez, Rafael, Hou, Xiaonan, Weroha, Saravut J., Wang, Liguo, Shi, Lei, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588789/
https://www.ncbi.nlm.nih.gov/pubmed/36274096
http://dx.doi.org/10.1038/s41467-022-34024-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588789/
https://www.ncbi.nlm.nih.gov/pubmed/36274096
http://dx.doi.org/10.1038/s41467-022-34024-y

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