Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Immunoglobulin M (IgM) is the most ancient of the five isotypes of immunoglobulin (Ig) molecules and serves as the first line of defence against pathogens. Here, we use cryo-EM to image the structure of the human full-length IgM pentamer, revealing antigen binding domains flexibly attached to the as...

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Detalles Bibliográficos
Autores principales: Chen, Qu, Menon, Rajesh, Calder, Lesley J., Tolar, Pavel, Rosenthal, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588798/
https://www.ncbi.nlm.nih.gov/pubmed/36274064
http://dx.doi.org/10.1038/s41467-022-34090-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588798/
https://www.ncbi.nlm.nih.gov/pubmed/36274064
http://dx.doi.org/10.1038/s41467-022-34090-2

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