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Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer
Immunoglobulin M (IgM) is the most ancient of the five isotypes of immunoglobulin (Ig) molecules and serves as the first line of defence against pathogens. Here, we use cryo-EM to image the structure of the human full-length IgM pentamer, revealing antigen binding domains flexibly attached to the as...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588798/ https://www.ncbi.nlm.nih.gov/pubmed/36274064 http://dx.doi.org/10.1038/s41467-022-34090-2 |