Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation

Effective drugs for atrial fibrillation (AF) are lacking, resulting in significant morbidity and mortality. This study demonstrates that network proximity analysis of differentially expressed genes from atrial tissue to drug targets can help prioritize repurposed drugs for AF. Using enrichment analy...

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Detalles Bibliográficos
Autores principales: Lal, Jessica C., Mao, Chengsheng, Zhou, Yadi, Gore-Panter, Shamone R., Rennison, Julie H., Lovano, Beth S., Castel, Laurie, Shin, Jiyoung, Gillinov, A. Marc, Smith, Jonathan D., Barnard, John, Van Wagoner, David R., Luo, Yuan, Cheng, Feixiong, Chung, Mina K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588904/
https://www.ncbi.nlm.nih.gov/pubmed/36223777
http://dx.doi.org/10.1016/j.xcrm.2022.100749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588904/
https://www.ncbi.nlm.nih.gov/pubmed/36223777
http://dx.doi.org/10.1016/j.xcrm.2022.100749

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